4.

Association of ≥20 years of smoking, obesity, VDR-BsmI genotype, and VDR-FokI genotype as single or combined with variables of melanoma.

Single or combined variable	Adjusted1 OR (CI), P (All melanoma cases vs. healthy controls)	Adjusted2 OR (CI), P (Melanomas vs. healthy controls)	Adjusted1 OR (CI), P (MetM vs. healthy controls)	Adjusted2 OR (CI), P (MetM vs. healthy controls)	Adjusted1 OR (CI), P (NMetM vs. healthy controls)	Adjusted2 OR (CI), P (NMetM vs. healthy controls)
1Adjusted OR (CI) for gender, and age. 2Adjusted OR for gender, age, phototype 1+2, total body nevi >50, and >10 lifelong sunburns. aOR uncountable because one of the compared group had zero subject. Significant differences were indicated in bold, tendencies were evidenced with superscript ^.
≥20 years of ever-smoking	2.19 (1.13–4.24), 0.020	1.79 (0.85–3.74), 0.124	3.16 (1.44–6.95), 0.004	2.46 (1.00–6.05), 0.050	1.50 (0.69–3.28), 0.304	1.13 (0.47–2.73), 0.789
BMI >30 kg/m2	3.20 (1.12–9.14), 0.030	5.28 (1.73–16.1), 0.003	3.95 (1.22–12.8), 0.022	7.74 (2.02–29.6), 0.003	2.51 (0.76–8.33), 0.132	3.69 (1.04–13.1), 0.043
BB	0.92 (0.51–1.66), 0.777	0.99 (0.52–1.91), 0.982	0.76 (0.34–1.68), 0.495	0.93 (0.39–2.25), 0.881	1.06 (0.54–2.08), 0.874	1.01 (0.48–2.12), 0.975
Bb	1.47 (0.87–2.49), 0.147	1.48 (0.83–2.63), 0.186	1.09 (0.56–2.12), 0.808	0.89 (0.41–1.92), 0.768	1.88 (1.01–3.49), 0.045	2.15 (1.09–4.25), 0.028
bb	0.66 (0.36–1.20), 0.171	0.61 (0.31–1.18), 0.140	1.15 (0.56–2.35), 0.705	1.21 (0.53–2.77), 0.644	0.36 (0.16–0.81), 0.013	0.30 (0.12–0.75), 0.010
BB+Bb (B allele)	1.52 (0.83–2.76), 0.171	1.65 (0.85–3.19), 0.140	0.87 (0.42–1.78), 0.705	0.82 (0.36–1.88), 0.644	2.81 (1.24–6.36), 0.013	3.30 (1.34–8.15), 0.010
Bb+bb (b allele)	1.09 (0.60–1.97), 0.777	1.01 (0.52–1.94), 0.982	1.32 (0.60–2.92), 0.495	1.07 (0.44–2.58), 0.881	0.95 (0.48–1.86), 0.874	0.99 (0.47–2.08), 0.975
bb plus ≥20 years of smoking	4.16 (0.86–20.2), 0.077^	3.24 (0.58–17.9), 0.179	6.81 (1.27–36.6), 0.025	6.99 (1.08–45.2), 0.041	1.68 (0.23–12.4), 0.612	0.98 (0.10–9.54), 0.987
Bb+bb plus ≥20 years of smoking	2.08 (1.00–4.29), 0.049	1.75 (0.78–3.92), 0.171	3.29 (1.42–7.60), 0.005	2.42 (0.93–6.28), 0.070^	1.19 (0.49–2.89), 0.702	0.94 (0.36–2.51), 0.910
bb plus BMI >30 kg/m2	–a	–a	–a	–a	–a	–a
Bb+bb plus BMI >30 kg/m2	3.20 (1.00–10.3), 0.050	4.35 (1.28–14.8), 0.018	4.34 (1.22–15.5), 0.024	6.55 (1.60–26.9), 0.009	2.26 (0.58–8.85), 0.242	2.81 (0.67–11.8), 0.158
Bb+bb plus ≥20 years of smoking, and plus BMI >30 kg/m2	8.61 (1.06–69.8), 0.044	12.0 (1.40–104), 0.024	17.4 (2.07–146), 0.008	22.7 (2.46–209), 0.006	1.93 (0.12–32.1), 0.646	2.68 (0.14–49.8), 0.508
FF	0.80 (0.47–1.36), 0.413	0.90 (0.50–1.62), 0.732	0.59 (0.29–1.20), 0.145	0.60 (0.27–1.33), 0.206	0.97 (0.53–1.80), 0.935	1.12 (0.57–2.19), 0.749
Ff	1.30 (0.77–2.20), 0.317	1.21 (0.68–2.17), 0.516	1.70 (0.87–3.35), 0.122	1.59 (0.73–3.45), 0.243	1.11 (0.60–2.05), 0.728	1.03 (0.53–2.03), 0.923
ff	0.88 (0.39–1.98), 0.758	0.81 (0.33–1.96), 0.638	0.90 (0.32–2.54), 0.846	1.08 (0.34–3.41), 0.902	0.82 (0.31–2.14), 0.682	0.72 (0.25–2.03), 0.531
FF+Ff (F allele)	1.13 (0.51–2.55), 0.758	1.24 (0.51–3.01), 0.638	1.11 (0.39–3.12), 0.846	0.93 (0.29–2.95), 0.902	1.22 (0.47–3.21), 0.682	1.39 (0.49–3.96), 0.531
Ff+ff (f allele)	1.25 (0.73–2.12), 0.413	1.11 (0.62–1.99), 0.732	1.69 (0.83–3.43), 0.145	1.68 (0.75–3.74), 0.206	1.03 (0.55–1.89), 0.935	0.90 (0.46–1.75), 0.749
Ff plus ≥20 years of smoking	2.77 (1.10–6.98), 0.031	2.36 (0.84–6.58), 0.102	4.02 (1.45–11.1), 0.007	3.69 (1.12–12.2), 0.032	1.78 (0.59–5.39), 0.307	1.48 (0.42–5.23), 0.545
Ff+ff plus ≥20 years of smoking	2.86 (1.24–6.60), 0.013	2.30 (0.91–5.82), 0.080^	4.21 (1.65–10.7), 0.003	3.92 (1.31–11.7), 0.014	1.83 (0.68–4.93), 0.234	1.31 (0.42–4.11), 0.646
Ff plus BMI >30 kg/m2	4.41 (0.92–21.1), 0.063^	6.91 (1.35–35.4), 0.020	6.09 (1.11–33.4), 0.037	14.6 (2.16–98.3), 0.006	3.61 (0.63–20.5), 0.148	4.39 (0.71–27.2), 0.112
Ff+ff plus BMI >30 kg/m2	6.09 (1.32–28.0), 0.020	8.89 (1.82–43.4), 0.007	8.50 (1.66–43.4), 0.010	17.8 (2.82–112), 0.002	4.53 (0.85–24.3), 0.078^	5.63 (0.98–32.4), 0.053^