. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Cancer. 2017 Apr 27;123(17):3410–3419. doi: 10.1002/cncr.30742

Table 2.

Association of Fatigue with Neurocognitive and Behavioral Outcomes

	Cognitive fatigue^{^}				Sleep-rest fatigue^{^}				General fatigue^{^}
	Males		Females		Males		Females		Males		Females
	r_p	P	r_p	P	r_p	P	r_p	P	r_p	P	r_p	P
Neurocognitive Function^{^}
Executive function
Cognitive flexibility	0.02	0.91	0.20	0.26	0.21	0.29	0.06	0.76	0.06	0.75	0.41	0.02
Verbal fluency	0.14	0.47	0.11	0.54	0.12	0.54	−0.11	0.54	−0.14	0.48	0.20	0.27
Working memory	−0.43	0.02	0.17	0.35	−0.12	0.54	0.19	0.30	−0.18	0.37	0.02	0.91
Organization	−0.42	0.03	0.06	0.77	−0.31	0.11	−0.08	0.66	−0.08	0.68	0.20	0.28
Abstract reasoning	0.005	0.98	−0.02	0.90	0.17	0.40	−0.26	0.15	−0.01	0.97	0.28	0.13
Processing speed
Motor	0.29	0.15	0.33	0.07	0.14	0.49	0.06	0.73	0.12	0.55	0.56	0.0009
Visual	−0.05	0.80	0.19	0.30	−0.26	0.19	0.04	0.81	−0.28	0.16	0.11	0.57
Visual-motor (coding)	−0.002	0.99	0.12	0.52	−0.13	0.50	−0.06	0.73	−0.30	0.12	−0.07	0.71
Visual-motor (sequencing)	−0.13	0.52	0.22	0.22	−0.13	0.51	−0.15	0.40	−0.26	0.19	0.001	0.99
Visual-verbal	−0.11	0.58	0.08	0.65	−0.28	0.16	−0.07	0.71	−0.03	0.87	0.47	0.006
Intelligence
Spatial intelligence	−0.20	0.32	0.21	0.25	0.02	0.90	0.22	0.22	−0.14	0.50	0.11	0.53
Attention
Omission	−0.28	0.15	0.26	0.15	−0.18	0.38	−0.24	0.19	−0.14	0.48	0.29	0.11
Variability	0.09	0.67	0.33	0.07	−0.12	0.54	−0.01	0.97	−0.29	0.14	0.36	0.04
Perseveration	−0.05	0.79	0.45	0.01	0.01	0.94	−0.01	0.96	0.18	0.36	0.55	0.001
Vigilance	−0.01	0.97	0.31	0.08	−0.20	0.31	−0.04	0.82	−0.29	0.15	0.39	0.03
Memory:
Digit Span	−0.11	0.58	0.34	0.05	0.19	0.35	−0.03	0.89	−0.22	0.27	0.12	0.50
Spatial Span	0.06	0.75	−0.12	0.50	0.17	0.41	−0.21	0.25	0.02	0.91	−0.04	0.84
Neurobehavioral Symptoms^#
Initiate	−0.05	0.83	−0.54	0.004	−0.01	0.97	−0.37	0.06	0.04	0.88	−0.21	0.30
Organization of materials	0.13	0.58	−0.33	0.09	0.18	0.44	−0.09	0.66	0.06	0.81	−0.13	0.52
Planning/organize	0.12	0.61	−0.53	0.001	0.12	0.62	−0.12	0.56	0.15	0.53	−0.28	0.15
Working memory	−0.14	0.55	−0.49	0.01	−0.10	0.66	−0.18	0.37	0.13	0.57	−0.25	0.21
Behavioral Symptoms^#
Inattention	−0.73	0.001	−0.77	<0.0001	−0.66	0.003	−0.14	0.47	−0.52	0.03	−0.71	<0.0001
Hyperactivity/Impulsivity	−0.42	0.08	−0.63	0.0004	−0.31	0.21	−0.20	0.32	−0.47	0.05	−0.73	<0.0001
Learning problems	−0.61	0.01	−0.64	0.0003	−0.45	0.06	0.11	0.59	−0.22	0.39	−0.59	0.001
Defiance/aggression	−0.17	0.49	−0.44	0.02	−0.30	0.22	−0.07	0.72	−0.10	0.69	−0.61	0.0008

^{^}

Higher scores for these measures are indicative of better functioning

Higher scores for these measures are indicative of worse functioning

r_p: For descriptive purpose, partial correlation coefficient (r_p) was presented to denote the strength of association between fatigue measures, with each neurocognitive and behavioral outcome, adjusted for age at evaluation.