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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Tuberculosis (Edinb). 2017 Jul 24;106:99–105. doi: 10.1016/j.tube.2017.07.009

Figure 3.

Figure 3

Histopathology assessment of the lungs in guinea pigs vaccinated with BCG or ST28 at day 40 after low dose aerosol challenge with M. tuberculosis H37Rv. Photomicrographs illustrate the extent of lung pathology for each group, where Group 1 = Saline-treated (guinea pig #2), Group 2 = BCG vaccinated (guinea pig #10) and Group 3 = ST28 inoculated (guinea pig #14). Granulomas with central necrosis were frequent in the saline-group, while granulomatous inflammation without necrosis occurred in some BCG-inoculated animals. Only minimal interstitial leukocyte infiltration occurred in the ST28 inoculated animals. Top panels: 20X, bottom panels: 100X magnification. The bar charts represent the mean pathology score for each group as described in the Materials and Methods. N = 5 guinea pigs per group. * p<0.05, *** p<0.001.