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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Hepatology. 2017 Jul 20;66(3):936–952. doi: 10.1002/hep.29229

Figure 8.

Figure 8

Palmitate-reduced intracellular O2•− is associated with MnSOD deacetylation. (A) HepG2 cells were treated with 0.5 mM PA for 12 h. Acetylated-MnSOD was detected. (B) & (C) HepG2 cells were treated with 0.5 mM PA for 12 h. Rotenone (10 nM) was added 1 h before PA treatment. Intracellular O2•− level was detected. All values are denoted as means ± SD. Bars with different characters differ significantly, p ˂ 0.05. (D) The proposed model of SIRT3-mediated hepatocyte susceptibility to lipotoxicity. The dotted lines denote the potential alternative mechanisms which were not investigated by the current study.