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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Hepatology. 2017 Jul 27;66(3):983–985. doi: 10.1002/hep.29272

Figure 1.

Figure 1

Schematic overview of receptor-interacting kinase 1 (RIPK1) and TNF receptor-associated factor 2 (TRAF2) role in spontaneous liver carcinogenesis. Simplified illustration demonstrates that single RIPK1 or TRAF2 deletion in liver parenchymal cells does not lead to liver carcinogenesis. In contrast, simultaneous loss of both RIPK1 and TRAF2 in liver parenchymal cells results in impaired canonical NF-κB signaling, caspase 8 activation, increased apoptosis and spontaneous development of hepatocellular carcinoma (HCC).