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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Hepatology. 2017 Jul 18;66(3):746–757. doi: 10.1002/hep.29170

Figure 1. Conditioned medium from HCV exposed macrophages activates proinflammatory molecules in human hepatic stellate cells.

Figure 1

Panel A. LX2 cells were incubated with CM from mock (control CM) or HCV exposed macrophages CM (HCV-MΦ-CM) for 48 h. Expression of inflammasome markers, NLRP3, IL-1β, IL-6 and CCL5 genes, were examined by qRT-PCR. 18S RNA was used as an internal control. Panel B. Human primary hepatic stellate cells were similarly treated with control CM or HCV-MΦ-CM and inflammasome markers were examined. Values represent from three independent experiments ±SD. Statistical significance was analyzed using the two-tailed Student’s t test: *P < 0.05, **P<0.01.