Table 2.
Serum creatinine values and predictive model variables in development cohort in those with and without AKI
| ICU | Non-ICU | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Non-missing (1332) | No AKI (541) | AKI (791) | P-Value | Non-missing (2337) | No AKI (1615) | AKI (722) | P-Value | |
|
| ||||||||
| Baseline Serum Creatinine (mg/dL)a,b | 1332 | 0.36 (0.26–0.54) | 0.26 (0.19–0.41) | <0.001 | 0.42 (0.29–0.58) | 0.26 (0.18–0.41) | <0.001 | |
|
| ||||||||
| Peak Serum Creatinine (mg/dL)a,b | 1332 | 0.45 (0.31–0.63) | 0.56 (0.42–0.91) | <0.001 | 0.49 (0.34–0.67) | 0.53 (0.37–0.77) | <0.001 | |
|
| ||||||||
| Age (years)a | 1332 | 6.5 (1.4–13.6) | 2.6 (0.6–10.5) | <0.001 | 2337 | 10.6 (3.3–15.3) | 5.3 (2.0–12.4) | <0.001 |
|
| ||||||||
| High Risk Nephrotoxinsc | ||||||||
| 0 | 1332 | 428 (79) | 673 (85) | 0.02 | 2337 | 1195 (74) | 634 (88) | <0.001 |
| 1 | 91 (17) | 96 (12) | 311 (19) | 61 (8) | ||||
| ≥2 | 22 (4) | 22 (3) | 109 (7) | 27 (4) | ||||
|
| ||||||||
| Moderate Risk Nephrotoxinsc | ||||||||
| 0 | 1332 | 452 (84) | 557 (70) | <0.001 | 2337 | 1453 (90) | 671 (93) | 0.01 |
| 1 | 63 (12) | 151 (19) | 136 (8) | 36 (5) | ||||
| ≥2 | 26 (5) | 83 (10) | 26 (2) | 15 (2) | ||||
|
| ||||||||
| Total Medicationsa | 1332 | 4 (1–7) | 1 (0–9) | <0.001 | 2337 | 1 (0–4) | 0 (0–0) | <0.001 |
|
| ||||||||
| Minimum Platelet Count (×103/μL)a | 737 | 252 (184–330) | 161 (100–280) | <0.001 | 948 | 267 (198–350) | 234 (141–351) | 0.003 |
|
| ||||||||
| Median Red Cell Distribution Width (%)a | 677 | 13.4 (12.8–14.2) | 13.8 (13.0–14.7) | <0.001 | 953 | 13.3 (12.7–14.7) | 14.5 (13.0–16.3) | <0.001 |
|
| ||||||||
| Phosphorusc | ||||||||
| None Checked | 1332 | 485 (90) | 745 (94) | <0.001 | 2337 | 1451 (90) | 666 (92) | 0.04 |
| Normal | 46 (9) | 26 (3) | 122 (8) | 34 (5) | ||||
| High Value | 10 (2) | 20 (3) | 42 (3) | 22 (3) | ||||
|
| ||||||||
| Transaminasesc | ||||||||
| None Checked | 1332 | 408 (75) | 717 (91) | <0.001 | 2337 | 1191 (74) | 629 (87) | <0.001 |
| Normal | 79 (15) | 23 (3) | 225 (14) | 41 (6) | ||||
| High Value | 54 (10) | 51 (6) | 199 (12) | 52 (7) | ||||
|
| ||||||||
| Minimum pHa | 962 | 7.30 (7.24–7.36) | 7.25 (7.15–7.30) | <0.001 | -- | -- | -- | -- |
| Hypotensionc | 1332 | 132 (24) | 241 (30) | 0.02 | -- | -- | -- | -- |
a
Median (interquartile range), p-value from Wilcoxon rank-sum test;
b
Note that neither baseline nor peak serum creatinine is included as covariates in the predictive model;
c
Number, (%), p-value from Pearson chi square test. AKI – Acute Kidney Injury; ICU – Intensive Care Unit.