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VLX103 decreases cell death and increases survival. (A) TUNEL-stained livers from mice with the indicated treatments (200×). (B) Quantification of TUNEL-positive cells per high power field (HPF) (*P<0.0002 as compared to PBS + GalN/LPS; n=6-7). (C) Percentage survival after pretreatment with PBS or the indicated VLX103 concentrations and GalN/LPS (P<0.004 for 40 mg/kg and P<0.001 for 50 mg/kg; n=6-12).
