Table 1.
Baseline characteristics of study population, by APOL1 risk allele status.
| Characteristic | APOL1 Low-Risk (n=533) | APOL1 High-Risk (n=160) | P-value |
|---|---|---|---|
| Age at randomization, years | 54.8 ± 10.1 | 51.7 ± 11.8 | <0.01 |
| Female | 210 (39%) | 69 (43%) | 0.40 |
| European ancestry, % | 17 ± 14 | 16 ± 12 | 0.19 |
| Smoking | 0.73 | ||
| Never | 224 (42%) | 72 (45%) | |
| Current | 150 (28%) | 45 (28%) | |
| Past | 159 (30%) | 43 (27%) | |
| History of heart disease | 281 (53%) | 69 (43%) | 0.03 |
| Body mass index, kg/m2 | 30.9 ± 6.5 | 31.7 ± 7.2 | 0.23 |
| Systolic blood pressure, mmHg | 144 ± 23 | 141 ± 23 | 0.24 |
| Total cholesterol, mg/dL | 211 ± 44 | 213 ± 44 | 0.70 |
| eGFR, ml/min/1.73 m2 | 50.1 ± 14.7 | 44.7 ± 13.5 | <0.01 |
| Urine protein-to-creatinine ratio, g/g Cr | 0.06 (0.03 to 0.22) | 0.19 (0.04 to 0.72) | <0.01 |
| Randomized blood pressure goal | 0.99 | ||
| Low | 270 (51%) | 81 (51%) | |
| Usual | 263 (49%) | 79 (49%) | |
| Randomized blood pressure drug | 0.77 | ||
| Metoprolol | 205 (38%) | 66 (41%) | |
| Ramipril | 224 (42%) | 66 (41%) | |
| Amlodipine | 104 (20%) | 28 (18%) |
Values presented as mean ± standard deviation, median (interquartile range), or n (%).
APOL1 high-risk defined as having 2 risk variants and low-risk defined as having 0–1 risk variant. Abbreviations: eGFR=estimated glomerular filtration rate; Cr=creatinine.