Table 31.
ToxIC 2016 cases—clinical signs—other organ systems
| N (%)a | |
|---|---|
| Metabolic | |
| Elevated anion gap (>20) | 459 (5.4) |
| Metabolic acidosis (pH <7.2) | 387 (4.5) |
| Hypoglycemia (glucose <50 mg/dL) | 126 (1.5) |
| Elevated osmole gap (>20) | 61 (0.7) |
| Total | 1033 (12.1)b |
| Gastrointestinal/hepatic | |
| Hepatotoxicity (AST ≥1000 IU/L) | 296 (3.5) |
| Pancreatitis | 64 (0.8) |
| Gastrointestinal bleeding | 49 (0.6) |
| Corrosive injury | 42 (0.5) |
| Intestinal ischemia | 5 (0.1) |
| Total | 456 (5.3)b |
| Hematological | |
| Coagulopathy (PT >15 s) | 199 (2.3) |
| Leukocytosis (WBC >20 K/μL) | 131 (1.5) |
| Thrombocytopenia (platelets <100 K/μL) | 102 (1.2) |
| Hemolysis (Hgb <10 g/dL) | 56 (0.7) |
| Pancytopenia | 21 (0.2) |
| Methemoglobinemia (MetHgb ≥2%) | 18 (0.2) |
| Total | 527 (6.2)b |
| Renal/musculoskeletal | |
| Rhabdomyolysis (CPK >1000 IU/L) | 489 (5.7) |
| Acute kidney injury (creatinine >2.0 mg/dL) | 386 (4.5) |
| Total | 875 (10.3)b |
| Dermatological | |
| Rash | 165 (1.9) |
| Blister/bullae | 71 (0.8) |
| Necrosis | 31 (0.4) |
| Angioedema | 25 (0.3) |
| Total | 292 (3.4)b |
AST aspartate aminotransferase, PT prothrombin time, WBC white blood cells, Hgb hemoglobin, CPK creatine phosphokinase
aPercentage equals the number of cases reporting specific clinical signs compared to the total number of Registry cases in 2016 (N = 8529)
bTotal reflects cases reporting at least one sign in the category; cases may be associated with more than one symptom