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. 2017 Aug 1;13(3):203–226. doi: 10.1007/s13181-017-0627-3

Table 31.

ToxIC 2016 cases—clinical signs—other organ systems

N (%)a
Metabolic
 Elevated anion gap (>20) 459 (5.4)
 Metabolic acidosis (pH <7.2) 387 (4.5)
 Hypoglycemia (glucose <50 mg/dL) 126 (1.5)
 Elevated osmole gap (>20) 61 (0.7)
 Total 1033 (12.1)b
Gastrointestinal/hepatic
 Hepatotoxicity (AST ≥1000 IU/L) 296 (3.5)
 Pancreatitis 64 (0.8)
 Gastrointestinal bleeding 49 (0.6)
 Corrosive injury 42 (0.5)
 Intestinal ischemia 5 (0.1)
 Total 456 (5.3)b
Hematological
 Coagulopathy (PT >15 s) 199 (2.3)
 Leukocytosis (WBC >20 K/μL) 131 (1.5)
 Thrombocytopenia (platelets <100 K/μL) 102 (1.2)
 Hemolysis (Hgb <10 g/dL) 56 (0.7)
 Pancytopenia 21 (0.2)
 Methemoglobinemia (MetHgb ≥2%) 18 (0.2)
 Total 527 (6.2)b
Renal/musculoskeletal
 Rhabdomyolysis (CPK >1000 IU/L) 489 (5.7)
 Acute kidney injury (creatinine >2.0 mg/dL) 386 (4.5)
 Total 875 (10.3)b
Dermatological
 Rash 165 (1.9)
 Blister/bullae 71 (0.8)
 Necrosis 31 (0.4)
 Angioedema 25 (0.3)
 Total 292 (3.4)b

AST aspartate aminotransferase, PT prothrombin time, WBC white blood cells, Hgb hemoglobin, CPK creatine phosphokinase

aPercentage equals the number of cases reporting specific clinical signs compared to the total number of Registry cases in 2016 (N = 8529)

bTotal reflects cases reporting at least one sign in the category; cases may be associated with more than one symptom