Table 2.
Fulfilment of MDS criteria in 2000 cases with a clinical diagnosis of recent onset Parkinson's disease.
| Characteristic | All cases N = 2000 (100%) |
Fulfilment of MDS criteria for Parkinson's disease |
||
|---|---|---|---|---|
| Not PD N = 165 (8.3%) |
Clinically probable N = 574 (28.7%) |
Clinically established N = 1261 (63.1%) |
||
| Number of red flags | ||||
| 0 | 1712 (85.6%) | 111 (67.3%) | 340 (59.2%) | 1261 (100%) |
| 1 | 251 (12.6%) | 41 (24.8%) | 210 (36.6%) | Not applicable |
| 2 | 36 (1.8%) | 12 (7.3%) | 24 (4.2%) | Not applicable |
| >2 | 1 (0.1%) | 1 (0.6%) | 0 (0.0%) | Not applicable |
| Number of supporting criteria | ||||
| 0 | 55 (2.8%) | 13 (7.9%) | 42 (7.3%) | Not applicable |
| 1 | 387 (19.4%) | 43 (26.1%) | 344 (59.9%) | Not applicable |
| 2 | 874 (43.7%) | 65 (39.4%) | 92 (16.0%) | 717 (56.9%) |
| >2 | 684 (34.2%) | 44 (26.7%) | 96 (16.7%) | 544 (43.1%) |
| Number of absolute exclusion criteria | ||||
| 0 | 1851 (92.6%) | 16 (9.7%) | 574 (100.0%) | 1261 (100%) |
| 1 | 143 (7.2%) | 143 (86.7%) | Not applicable | Not applicable |
| >1 | 6 (0.3%) | 6 (3.6%) | Not applicable | Not applicable |
| Red flags | ||||
| Rapid gait progression | 3 (0.2%) | 0 (0.0%) | 3 (0.5%) | Not applicable |
| Absence of motor progression | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | Not applicable |
| Bulbar dysfunction | 115 (5.8%) | 29 (17.6%) | 86 (15.0%) | Not applicable |
| Respiratory dysfunction | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | Not applicable |
| Severe autonomic | 148 (7.4%) | 25 (15.2%) | 123 (21.4%) | Not applicable |
| Recurrent falls | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | Not applicable |
| Disproportionate anterocollis | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | Not applicable |
| Common non-motor absent | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | Not applicable |
| Pyramidal signs | 36 (1.8%) | 9 (5.5%) | 27 (4.7%) | Not applicable |
| Symmetric parkinsonism | 24 (1.2%) | 5 (3.0%) | 19 (3.3%) | Not applicable |
| Supporting criteria | ||||
| Clear l-dopa response | 1363 (68.2%) | 105 (63.6%) | 255 (44.4%) | 1003 (79.5%) |
| l-dopa induced dyskinesia | 94 (4.7%) | 7 (4.2%) | 22 (3.8%) | 65 (5.2%) |
| Rest tremor of a limb | 1585 (79.3%) | 111 (67.3%) | 348 (60.6%) | 1126 (89.3%) |
| Olfactory loss | 1181 (59.0%) | 87 (52.7%) | 198 (34.5%) | 896 (71.1%) |
| Absolute exclusion criteria | ||||
| Unequivocal cerebellar | 25 (1.3%) | 25 (15.2%) | Not applicable | Not applicable |
| Vertical gaze palsy | 117 (5.8%) | 117 (70.9%) | Not applicable | Not applicable |
| Fronto-temporal dementia/PPA | 0 (0.0%) | 0 (0.0%) | Not applicable | Not applicable |
| Parkinsonism in lower limbs only | 1 (0.1%) | 1 (0.6%) | Not applicable | Not applicable |
| Dopamine blocker/depleter | 2 (0.1%) | 2 (1.2%) | Not applicable | Not applicable |
| Absence of l-dopa response | 3 (0.2%) | 3 (1.8%) | Not applicable | Not applicable |
| Cortical sensory loss/apraxia | 8 (0.4%) | 8 (4.8%) | Not applicable | Not applicable |
| Normal functional dopamine imaging | 0 (0.0%) | 0 (0.0%) | Not applicable | Not applicable |
| Alternative parkinsonism documented | 0 (0.0%) | 0 (0.0%) | Not applicable | Not applicable |
MDS = Movement Disorder Society, PD = Parkinson's disease, PPA = Primary progressive aphasia.