Table 3.
No at risk | No. with CKD (%) | Age Gender Model | Multivariable Model* | |||
---|---|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |||
CRAE (µm) | ||||||
Tertile 3 (137.24–175.89) | 418 | 26 (6.22) | Referent | Referent | ||
Tertile 2 (127.42–137.23) | 419 | 20 (4.77) | 0.79 (0.45, 1.39) | 0.415 | 0.88 (0.47, 1.67) | 0.704 |
Tertile 1 (90.63–127.41) | 419 | 32 (7.64) | 1.00 (0.59, 1.71) | 0.979 | 1.02 (0.51, 2.07) | 0.952 |
CRAE per sd (11.91)↓ | 1256 | 78 (6.21) | 1.11 (0.90, 1.37) | 0.321 | 1.34 (1.00, 1.78) | 0.048 |
P-trend | 0.973 | 0.932 | ||||
CRVE (µm) | ||||||
Tertile 1 (118.81–195.79) | 418 | 22 (5.26) | Referent | Referent | ||
Tertile 2 (195.82–208.71) | 419 | 25 (5.97) | 1.94 (1.07, 3.49) | 0.028 | 2.65 (1.40, 5.03) | 0.003 |
Tertile 3 (208.72–256.95) | 419 | 31 (7.40) | 1.94 (1.11, 3.38) | 0.020 | 2.35 (1.12, 5.94) | 0.025 |
CRVE per sd (16.67)↑ | 1256 | 78 (6.21) | 1.2 (0.99, 1.46) | 0.064 | 1.25 (0.95, 1.65) | 0.116 |
P-trend | 0.021 | 0.024 | ||||
Arteriolar tortuosity, per sd (12.71 × 10−5)↓ | 1256 | 78 (6.21) | 1.35 (1.01, 1.81) | 0.045 | 1.28 (0.96, 1.70) | 0.088 |
Venular tortuosity, per sd (24.63 × 10−5)↓ | 1256 | 78 (6.21) | 1.03 (0.79, 1.35) | 0.486 | 1.24 (0.91, 1.68) | 0.171 |
Fractal dimension, per sd (0.044)↑ | 1256 | 78 (6.21) | 0.91 (0.73, 1.12) | 0.348 | 0.91 (0.72 1.14) | 0.401 |
Arteriolar branching angle, per sd (10.67)↑ | 1256 | 78 (6.21) | 1.18 (0.96, 1.45) | 0.118 | 1.14 (0.91, 1.37) | 0.306 |
Venular branching angle, per sd (9.92)↑ | 1256 | 78 (6.21) | 1.09 (0.87, 1.36) | 0.462 | 1.08 (0.88, 1.32) | 0.485 |
Any retinopathy, yes | 122 | 26 (21.3) | 4.12 (2.56, 6.62) | <0.001 | 2.54 (1.48, 4.36) | 0.001 |
CI: confidence interval; CRAE, central retinal arteriolar equivalent; CRVE, central retinal arteriolar equivalent; HR, hazard ratio; *adjusted for age, gender, baseline glucose levels, baseline SBP, hypertension, smoking status, hsCRP, education level, total cholesterol, HDL cholesterol, baseline eGFR, anti-hypertensive medication and retinal arteriolar caliber/retinal venular caliber (CRAE in models of CRVE and vice versa).