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. 2017 Aug 24;7:9399. doi: 10.1038/s41598-017-09978-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The linkage disequilibrium (LD) blocks (ATG5 and ATG16L1 genetic polymorphisms) and their locations in the genes. According to the GRCh38.p7 primary assembly, the human ATG5 and ATG16L1 genes are respectively located in Homo sapiens chromosome 6 (106,184,476–106,325,820) and Homo sapiens chromosome 2 (233,251,571–233,295,674). The rs506027 and rs510432 promoter polymorphisms are located in the upstream of the transcriptional start site (−769 bp and −335 bp), respectively. The rs548234 is located in the PRDM1-ATG5 intergenic region, and another promoter polymorphism of ATG16L1 rs10210302 is located in the upstream of the transcriptional start site (−1378 bp). Two haplotype blocks (rs506027–rs510432, D’ value = 100; rs10210302–rs2241880, D’ value = 100) are generated using Haploview 4.2.