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. 2017 Aug 24;7:9399. doi: 10.1038/s41598-017-09978-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Real-time PCR analysis of the ATG5 and ATG16L1 mRNA expression in sepsis patients and healthy controls. Expression levels of ATG5 and ATG16L1 in sepsis patients and healthy controls (A,B). Expression levels of ATG5 and ATG16L1 in mild sepsis, severe sepsis and septic shock subgroups (C,D). Expression levels of ATG5 and ATG16L1 in 28-day surviving and non-surviving sepsis patients (E,F). The distribution of ATG5 expression in groups of sepsis patients with different rs510432/rs506027 genotypes (G) and different rs548234 genotypes (I). The distribution of ATG16L1 expression in groups of sepsis patients with different rs10210302/rs2241880 genotypes (H). The horizontal line represents the mean expression levels of ATG5 and ATG16L1 with each group. *P < 0.05; **P < 0.01; ***P < 0.001.