Table 2.
Genotype and allele frequencies distribution in the different sepsis status.
| ATG SNP | Mild sepsis (n = 74) | Severe sepsis (n = 191) | Septic shock (n = 138) | Severe sepsis/Septic shock (n = 329) | P1 | P2 | P3 | P1* | P2* | P3* |
|---|---|---|---|---|---|---|---|---|---|---|
| rs510432/rs506027 | ||||||||||
| GG/TT | 34(45.9) | 57(29.8) | 44(31.9) | 101(30.7) | 0.013 | 0.043 | 0.012 | 0.026 | 0.043 | 0.020 |
| GA + AA/TC + CC | 40(54.1) | 134(70.2) | 94(68.1) | 228(69.3) | — | — | — | — | — | — |
| G/T | 100(67.6) | 222(58.1) | 154(55.8) | 376(57.1) | 0.046 | 0.018 | 0.020 | 0.046 | 0.036 | 0.020 |
| A/C | 48(32.4) | 160(41.9) | 122(44.2) | 282(42.9) | — | — | — | — | — | — |
| rs548234 | ||||||||||
| TT | 45(60.8) | 96(50.3) | 69(50.0) | 165(50.2) | 0.123 | 0.132 | 0.097 | 0.123 | 0.132 | 0.097 |
| CT + CC | 29(39.2) | 95(49.7) | 69(50.0) | 164(49.8) | — | — | — | — | — | — |
| T | 116(78.4) | 272(71.2) | 196(71.0) | 468(71.1) | 0.094 | 0.101 | 0.074 | 0.123 | 0.132 | 0.097 |
| C | 32(21.6) | 110(28.8) | 80(29.0) | 190(28.9) | — | — | - | — | — | — |
| rs10210302/rs2241880 | ||||||||||
| CC/AA | 31(41.9) | 84(44.0) | 67(48.6) | 151(45.9) | 0.758 | 0.354 | 0.532 | 0.758 | 0.354 | 0.532 |
| CT + TT/GA + GG | 43(58.1) | 107(56.0) | 71(51.4) | 178(54.1) | — | — | — | — | — | — |
| C/A | 94(63.5) | 249(65.2) | 194(70.3) | 443(67.3) | 0.718 | 0.154 | 0.374 | 0.758 | 0.308 | 0.532 |
| T/G | 54(36.5) | 133(34.8) | 82(29.7) | 215(32.7) | — | — | — | — | — | — |
P1: mild sepsis vs. severe sepsis; P2: mild sepsis vs. septic shock. *False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.