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. 2017 Aug 24;7:9285. doi: 10.1038/s41598-017-08249-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DACT1 inhibits ovarian tumourigenesis in vivo. (a) 5 * 10⁶ 3AO-DACT1 or 3AO-NC cells were injected into the subcutaneous tissue of each nude mouse (n = 5 animals per group). Average tumour volume was assessed weekly (*P < 0.05, paired t test). (b) Representative images of xenografts five weeks after injection. (c) Five weeks after injection, xenograft tumours were resected and measured. The average weight of the DACT1 over-expressing xenograft tumours was significantly lower than that of control xenograft tumours (*P < 0.05). (d) and (e) Proliferation indexes of DACT1 over-expressing and control xenograft tumours were evaluated by Ki-67. Cell proliferation was significantly higher in control xenograft tumours than DACT1 over-expressing tumours (***P < 0.001).