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. 2017 Aug 24;7:9294. doi: 10.1038/s41598-017-10175-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pedigree of the presently studied family with developmental dyslexia (DD). Open boxes/circles indicate individuals without DD (confirmed no DD diagnosis), filled boxes/circles indicate individuals with confirmed DD. A question mark indicates an unknown phenotype. The exome-sequenced individual is marked with a “WES” and the whole-genome sequenced individual is marked with a “WGS”. The genotype of each individual for both NCAN markers is shown: (A) rs146011974 (a rare variant, identified through exome sequencing) and (B) rs1064395, (common variant, used in the brain imaging analysis). Individuals without DNA sample are indicated by the # symbol. Individual 10 000 (marked with a star) was not included in the linkage analysis. N/A = Genotype not available.