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. 2017 Aug 24;7:9388. doi: 10.1038/s41598-017-10062-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of C37 on CRC tumor xenografts growth and lung metastases in mice. (A) Tumor volume of HCT116 xenografts in nude mice, randomized to receive C37, as described in the Methods section. (B) Number of surviving mice xenografted with HCT116 cells, after treatments with C37, as described in the Methods section. Median survival was 61.5 days in treated mice versus 41 days in control mice. (C) Western blot analysis on total lysates from HCT116 tumor specimens of mice sacrificed on day 21, after two weeks of treatment with C37. All immunoblot bands are cropped, full-length blot images for pPaxillin, Paxillin, pAKT and AKT are provided in Supplementary Figure S5. (D) Immunoistochemical analysis of Ki67, E-cadherin and vimentin expression on HCT116 tumor xenografts after treatments with C37 (E) Alu sequences quantification after artificial metastasis assay of HCT116 RAS mutated cells injected in tail vein of nude mice and treated with C37 or vehicle.