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. 2017 Aug 24;7:9273. doi: 10.1038/s41598-017-09548-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plot of genetic association for TM6SF2 E167K polymorphism on inflammation status in chronic hepatitis C patients. Pooled dichotomous odds ratio of TM6SF2 E167K variant (EK + KK) on severe inflammation^a compared to non-severe inflammation group in chronic hepatitis C patients. ^aSevere inflammation was defined as G13-G18 status in study applying Ishak criteria²⁵ and G4 status in study applying Scheuer²⁶ and METAVIR²⁷ criteria.