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. 2017 Aug 24;7:9371. doi: 10.1038/s41598-017-09907-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HG-treated cells undergoing the EndoMT secrete more exosomes than NG-treated GECs. (A) Exosomes extracted from GECs were observed by TEM. Magnification: ×150,000. (n = 4) (B) Protein blots of exosomes derived from the same number of NG- and HG-treated GECs using antibodies for calnexin, CD63 and CD9. In addition, the expression of calnexin in GECs was also examined by Western blotting. (n = 3 for each index) (C) Quantification of exosomes isolated from NG- and HG-treated GECs normalized by cell number. Compared to the NG-GEC-Exo group, HG-treated cells undergoing the EndoMT released a higher number of exosomes. The results are presented as the mean ± SD. *p < 0.05 versus NG-GEC-Exo group (Student’s t-test; n = 6). NG-GEC-Exo group, exosomes derived from NG-treated GECs; HG-GEC-Exo group, exosomes derived from HG-treated GECs.

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