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. 2017 Aug 24;7:9304. doi: 10.1038/s41598-017-09009-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Measured tau protein concentrations, ϕ_tau-IMR, in human plasma for healthy controls and various types of dementia, including VD (), PD (), MCI due to AD (), FTD (), and AD (). (b) ROC curve for discriminating between healthy controls and dementia subjects in terms of plasma tau protein concentration. The cutoff value of plasma tau protein concentration to discriminate healthy controls from dementia subjects was 17.43 pg/ml, as plotted with the dashed line in (a). The corresponding clinical sensitivity and specificity are 0.856 and 0.742, respectively. The area under the ROC curve is 0.907.

Inline graphic — (a) Measured tau protein concentrations, ϕ_tau-IMR, in human plasma for healthy controls and various types of dementia, including VD (), PD (), MCI due to AD (), FTD (), and AD (). (b) ROC curve for discriminating between healthy controls and dementia subjects in terms of plasma tau protein concentration. The cutoff value of plasma tau protein concentration to discriminate healthy controls from dementia subjects was 17.43 pg/ml, as plotted with the dashed line in (a). The corresponding clinical sensitivity and specificity are 0.856 and 0.742, respectively. The area under the ROC curve is 0.907.