FIG 2.

cDNA expression library screening to identify the syncytin-A partner of fusion. (A) Scheme of the screening of a mouse cDNA expression library by cell-cell fusion, which resulted in the identification of Ly6e as the potential receptor of SynA. Representative cell images of each step of the screening are shown with the range of syncytium numbers per well. (B) Scheme of mouse immature and mature Ly6e protein. In the mature form, the extracellular domain (in red) is attached to the plasma membrane by a GPI anchor on the amino acid residue boxed in the immature form after cleavage of the signal peptide (in gray) and the propeptide sequences (in white).