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Schematic illustration of HIV-1 gp41 protein and its NHR- and CHR-derived peptides. The gp41 numbering of HIV-1HXB2 was used. TM, transmembrane domain. The positions and sequences corresponding to the T20-resistant site and pocket-forming site in the NHR are marked in blue. The positions and sequences corresponding to the M-T hook structure, PBD, and tryptophan-rich motif in the CHR are marked in green, red, and purple, respectively. “C16” in inhibitors represents a fatty acid group.
