FIG 4.

Binding models of membrane-anchoring lipopeptides. Both classes of lipopeptide inhibitors can bind to the extended PHI during the early stage of viral membrane fusion. LP-11 mainly targets the pocket site located at the extreme C terminus of the NHR helices, and thus, it needs a long linker to reach the position (binding mode I). LP-40 targets the membrane-proximal NHR site, and its anchoring via a lipid molecule does not affect its binding (binding mode II). Red represents peptide sequences, purple represents fatty acid molecules, and the black line represents a PEG 8 linker.