FIG 5.
Synergistic anti-HIV effects of LP-40 and LP-11. The synergistic inhibition by inhibitors of diverse HIV-1 pseudoviruses was determined by single-cycle infection assay. Peptides were tested individually and in combination at a fixed molar ratio achieving equivalent IC50s. LP-40/LP-11 ratios, 3:1 (A), 1:2 (B), and 2:1 (C). Each sample was tested in triplicate, and the experiment was repeated 3 times. An NL4-3 pseudovirus with a D36G mutation in gp41 was used. The error bars indicate standard deviations (SD).