FIG 9.

Interactions of N and C termini of LP-40 in the 6-HB crystal structure. Hydrophobic interactions of LP-40 are presented horizontally in a ribbon model (PyMol). The N44 trimer is colored gray. Residues related to hydrogen bonds are shown as stick models in gray. Hydrophobic amino acids related to hydrophobic interaction on the N44 trimer are shown as stick models and colored in corresponding colors. LP-40 inhibitors are green. Hydrophobic amino acids related to hydrophobic interaction on LP-40 are shown as stick models and colored in corresponding colors. The N and C termini of LP-40 and the N terminus of N44 are labeled.