TABLE 1.
Ten most significant canonical pathways of 806 ORFs
| Canonical pathway | Genes | P valuea |
|---|---|---|
| Intrinsic prothrombin activation pathway | COL3A1, KLK3, COL11A2, F5, SERPINC1 | 1.45E−03 |
| Role of Wnt/GSK-3β signaling in the pathogenesis of influenza virus | CSNK1E, WNT5A, DVL2, IFNB1, APC2, IFNA4, WNT9A | 1.78E−03 |
| G-protein-coupled receptor signaling | ADORA2A, VIPR2, GABBR1, PDE1B, PIK3C2B, GNAL, PRKAR1A, DRD1, GABBR2, GNAS, MAP3K8, DRD4, HTR2C, GRM1, CHRM4, ADRA2A | 7.24E−03 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza virus | CXCL10, IL-6, IFNB1, IFNA4 | 8.32E03 |
| CDK5 signaling | DRD1, GNAS, CDK5R1, LAMB1, PPP1CB, GNAL, PPP2CA, PRKAR1A | 8.91E−03 |
| Retinoic acid-mediated apoptosis signaling | TIPARP, CRABP2, IFNB1, RARB, IFNA4 | 9.12E−03 |
| Extrinsic prothrombin activation pathway | F3, F5, SERPINC1 | 1.07E−02 |
| Axonal guidance signaling | MYL4, SEMA3E, WNT5A, PGF, SEMA3B, PIK3C2B, EPHB2, SRGAP1, RGS3, GNAL, PRKAR1A, ABLIM3, GNAS, SLIT2, SEMA6C, BMP4, SEMA3A, NFAT5, SRGAP2, EFNA2, PLXNA, WNT9A | 1.45E−02 |
| cAMP-mediated signaling | ADORA2A, VIPR2, GABBR1, PDE1B, GNAL, PRKAR1A, DRD1, GABBR2, GNAS, DRD4, CHRM4, ADRA2A, PKIB | 1.55E−02 |
| Role of lipids/lipid rafts in the pathogenesis of influenza virus | IFNB1, IFNA4 | 2.57E−02 |
a
A canonical pathway was considered significant if P was <0.05. Data were analyzed using Qiagen's Ingenuity pathway analysis (IPA).