TABLE 1.

Phenotype (MIC), beta-lactamase genotype, and pharmacodynamic characteristics of the isolates used in the experiments

Isolate	Resistance summary	MIC (mg/liter) of FEPa combined with the following concn of tazobactam (mg/liter):											FEP %fTMIC for a static effect
		0	0.031	0.063	0.125	0.25	0.5	1	2	4	8	16
E. coli
5	CTX-M-9, OXA-1	8	16	32	32	4	0.25	0.125	0.125	0.125	0.125	0.125	0.6
56	CTX-M-15, TEM-1	>32	8	8	8	2	0.25	2	0.125	0.125	0.064	0.125	0
82	CTX-M-14, TEM-1	>32	32	32	32	32	16	16	2	0.064	0.064	0.064	<28.8
K. pneumoniae
58	TEM-84, SHV-11	4	4	4	4	2	2	1	0.25	0.5	0.125	0.125	37.7
74	CTX-M-1	>32	16	16	16	16	16	0.25	0.25	0.25	0.064	0.125	0
E. cloacae 27	CTX-M-39, inducible AmpC	>32	16	16	16	16	4	1	2	0.5	0.5	0.5	0

^aFEP, cefepime.