TABLE 2.
Static doses and %fT>CT of tazobactam in q2h dosing regimens for 6 isolatesa
| Isolate | FEP MIC (mg/liter) | FEP dose (mg/kg) | TDD of TZB (mg/kg) for a static effect | %fT>CTb for a TZB CT (mg/liter) of: |
||||
|---|---|---|---|---|---|---|---|---|
| 0.125 | 0.25 | 0.5 | 1 | 2 | ||||
| E. coli | ||||||||
| 5 | 8 | 1 | 9.6 | 20.3 | 11.4 | 2.4 | 0.0 | 0.0 |
| 56 | >32 | 1 | 24.4 | 32.2 | 23.3 | 14.3 | 4.9 | 0.0 |
| 82 | >32 | 1 | 67.6 | 45.2 | 36.3 | 27.4 | 18.2 | 9.1 |
| K. pneumoniae | ||||||||
| 58 | 4 | 1 | 44.1 | 39.7 | 30.8 | 21.9 | 12.6 | 3.5 |
| 74 | >32 | 1 | 15.1 | 26.0 | 17.1 | 8.1 | 0.0 | 0.0 |
| E. cloacae 27 | >32 | 1 | 37.7 | 37.7 | 28.8 | 19.9 | 10.6 | 1.4 |
a
FEP, cefepime; TZB, tazobactam.
b
The mean (SD) %fT>CT was 33.5% (9.2%) for a tazobactam CT of 0.125 mg/liter, 24.6% (9.2%) for 0.25 mg/liter, and 15.6% (9.3%) for 0.5 mg/liter.