TABLE 2.
In vitro activity of cefiderocol and comparators against Gram-negative bacilli (n = 4,966) isolated by 49 medical center laboratories in Europe from 2014 to 2015
| Family/genus/species (no. of isolates) | Antimicrobial agent | MIC (μg/ml)a |
MIC interpretationb |
||||
|---|---|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | % susceptible | % intermediate | % resistant | ||
| Enterobacteriaceae (3,080) | Cefiderocol | ≤0.002–8 | 0.12 | 1 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | >64 | 81.6 | 3.1 | 15.4 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.5 | 98.6 | 0 | 1.4 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.25 | 8 | 87.1 | 2.4 | 10.5 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | >8 | 80.5 | 1.8 | 17.8 | |
| Colistin | ≤0.25 to >8 | 0.5 | >8 | 82.0 | 0 | 18.0 | |
| Meropenem | ≤0.06 to >64 | ≤0.06 | 0.12 | 95.0 | 0.5 | 4.1 | |
| Meropenem-nonsusceptible Enterobacteriaceae (139) | Cefiderocol | 0.008–8 | 1 | 4 | |||
| Cefepime | 0.25 to >64 | >64 | >64 | 6.5 | 1.4 | 92.1 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 1 | >64 | 71.9 | 0 | 28.1 | |
| Ceftolozane-tazobactam | 0.5 to >64 | >64 | >64 | 5.0 | 2.2 | 92.8 | |
| Ciprofloxacin | ≤0.12 to >8 | >8 | >8 | 10.8 | 1.4 | 87.8 | |
| Colistin | ≤0.25 to >8 | 1 | >8 | 72.7 | 0 | 27.3 | |
| Meropenem | 2 to >64 | 16 | >64 | 0 | 10.1 | 89.9 | |
| Klebsiella spp.c (1,021) | Cefiderocol | ≤0.002–8 | 0.12 | 2 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | >64 | 70.3 | 3.3 | 26.4 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 1 | 97.8 | 0 | 2.3 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.25 | 64 | 83.0 | 1.3 | 15.8 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | >8 | 72.3 | 2.6 | 25.1 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 95.0 | 0 | 5.0 | |
| Meropenem | ≤0.06 to >64 | ≤0.06 | 2 | 89.9 | 1.0 | 9.1 | |
| Klebsiella pneumoniae (761) | Cefiderocol | ≤0.002–8 | 0.12 | 2 | |||
| Cefepime | ≤0.06 to >64 | 0.12 | >64 | 63.1 | 3.0 | 33.9 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.25 | 1 | 97.1 | 0 | 2.9 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.5 | 64 | 78.2 | 1.3 | 20.5 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | >8 | 64.4 | 2.8 | 32.9 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 93.3 | 0 | 6.7 | |
| Meropenem | ≤0.06 to >64 | ≤0.06 | 8 | 86.7 | 1.3 | 12.0 | |
| Klebsiella oxytoca (260) | Cefiderocol | ≤0.002–2 | 0.03 | 0.25 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 1 | 91.5 | 4.2 | 4.2 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.25 | 99.6 | 0 | 0.4 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.25 | 0.5 | 96.9 | 1.2 | 1.9 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | ≤0.12 | 95.4 | 2.3 | 2.3 | |
| Colistin | ≤0.25–2 | 0.5 | 1 | 100 | 0 | 0 | |
| Meropenem | ≤0.06–8 | ≤0.06 | ≤0.06 | 99.2 | 0 | 0.8 | |
| Escherichia coli (789) | Cefiderocol | ≤0.002–4 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 64 | 81.6 | 3.6 | 14.8 | |
| Ceftazidime-avibactam | ≤0.06–32 | 0.12 | 0.25 | 99.8 | 0 | 0.3 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.25 | 0.5 | 96.5 | 0.4 | 3.2 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | >8 | 72.9 | 0.5 | 26.6 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 99.5 | 0 | 0.5 | |
| Meropenem | ≤0.06–4 | ≤0.06 | ≤0.06 | 99.6 | 0 | 0.4 | |
| Serratia spp.d (493) | Cefiderocol | ≤0.002–8 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | 0.12 | 0.5 | 94.1 | 1.0 | 4.9 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.5 | 99.2 | 0 | 0.8 | |
| Ceftolozane-tazobactam | 0.12 to >64 | 0.5 | 1 | 95.3 | 1.8 | 2.8 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 1 | 93.7 | 2.2 | 4.1 | |
| Colistin | 0.5 to >8 | >8 | >8 | 5.1 | 0 | 94.9 | |
| Meropenem | ≤0.06–64 | ≤0.06 | 0.12 | 99.0 | 0 | 1.0 | |
| Serratia marcescens (455) | Cefiderocol | ≤0.002–8 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | 0.12 | 0.5 | 93.6 | 1.1 | 5.3 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.5 | 99.1 | 0 | 0.9 | |
| Ceftolozane-tazobactam | 0.25 to >64 | 0.5 | 1 | 95.2 | 2.0 | 2.9 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 1 | 93.4 | 2.4 | 4.2 | |
| Colistin | 0.5 to >8 | >8 | >8 | 5.5 | 0 | 94.5 | |
| Meropenem | ≤0.06–64 | ≤0.06 | 0.12 | 98.9 | 0 | 1.1 | |
| Serratia liquefaciens (33) | Cefiderocol | 0.015–0.25 | 0.06 | 0.12 | |||
| Cefepime | ≤0.06–0.25 | ≤0.06 | 0.12 | 100 | 0 | 0 | |
| Ceftazidime-avibactam | 0.12–1 | 0.25 | 0.5 | 100 | 0 | 0 | |
| Ceftolozane-tazobactam | 0.25–1 | 0.5 | 1 | 100 | 0 | 0 | |
| Ciprofloxacin | ≤0.12–0.5 | ≤0.12 | ≤0.12 | 100 | 0 | 0 | |
| Colistin | >8 | >8 | >8 | 0 | 0 | 100 | |
| Meropenem | ≤0.06–0.25 | ≤0.06 | 0.12 | 100 | 0 | 0 | |
| Enterobacter spp.e (530) | Cefiderocol | 0.008–8 | 0.25 | 1 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 16 | 85.7 | 4.2 | 10.2 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.25 | 0.5 | 97.9 | 0 | 2.1 | |
| Ceftolozane-tazobactam | ≤0.06–64 | 0.5 | 8 | 75.7 | 7.6 | 16.8 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 1 | 90.0 | 2.1 | 7.9 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 94.3 | 0 | 5.7 | |
| Meropenem | ≤0.06–64 | ≤0.06 | 0.12 | 96.2 | 0.6 | 3.2 | |
| Enterobacter cloacae (301) | Cefiderocol | 0.008–4 | 0.25 | 1 | |||
| Cefepime | ≤0.06 to >64 | 0.12 | 32 | 78.4 | 6.6 | 15.0 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.25 | 1 | 96.4 | 0 | 3.7 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.5 | 16 | 74.1 | 3.0 | 22.9 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 8 | 85.1 | 2.7 | 12.3 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 95.7 | 0 | 4.3 | |
| Meropenem | ≤0.06–64 | ≤0.06 | 0.25 | 93.7 | 1.0 | 5.3 | |
| Enterobacter aerogenes (204) | Cefiderocol | 0.015–8 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 1 | 94.6 | 1.0 | 4.4 | |
| Ceftazidime-avibactam | ≤0.06–8 | 0.25 | 0.5 | 100 | 0 | 0 | |
| Ceftolozane-tazobactam | 0.12–32 | 0.5 | 4 | 77.0 | 14.2 | 8.8 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 0.25 | 96.1 | 1.5 | 2.5 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 98.5 | 0 | 1.5 | |
| Meropenem | ≤0.06–64 | ≤0.06 | 0.12 | 99.5 | 0 | 0.5 | |
| Citrobacter spp.f (247) | Cefiderocol | 0.004–4 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 1 | 94.3 | 2.0 | 3.6 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.5 | 98.4 | 0 | 1.6 | |
| Ceftolozane-tazobactam | 0.12 to >64 | 0.25 | 8 | 82.6 | 3.2 | 14.2 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 1 | 91.5 | 0.4 | 8.1 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 99.6 | 0 | 0.4 | |
| Meropenem | ≤0.06–8 | ≤0.06 | ≤0.06 | 96.8 | 0.4 | 2.8 | |
| Citrobacter freundii (160) | Cefiderocol | 0.004–2 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | ≤0.06 | 2 | 92.5 | 2.5 | 5.0 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 0.12 | 0.5 | 98.1 | 0 | 1.9 | |
| Ceftolozane-tazobactam | 0.12 to >64 | 0.25 | 16 | 75.6 | 3.8 | 20.6 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | 4 | 88.1 | 0 | 11.9 | |
| Colistin | ≤0.25–2 | 0.5 | 1 | 100 | 0 | 0 | |
| Meropenem | ≤0.06–8 | ≤0.06 | 0.12 | 95.6 | 0.6 | 3.8 | |
| Citrobacter koseri (73) | Cefiderocol | 0.008–4 | 0.25 | 0.5 | |||
| Cefepime | ≤0.06–8 | ≤0.06 | ≤0.06 | 98.6 | 1.4 | 0 | |
| Ceftazidime-avibactam | ≤0.06–1 | 0.12 | 0.25 | 100 | 0 | 0 | |
| Ceftolozane-tazobactam | 0.12–4 | 0.25 | 0.5 | 98.6 | 1.4 | 0 | |
| Ciprofloxacin | ≤0.12 to >8 | ≤0.12 | ≤0.12 | 98.6 | 0 | 1.4 | |
| Colistin | ≤0.25 to >8 | 0.5 | 1 | 98.6 | 0 | 1.4 | |
| Meropenem | ≤0.06–0.12 | ≤0.06 | ≤0.06 | 100 | 0 | 0 | |
| Pseudomonas aeruginosa (765) | Cefiderocol | ≤0.002–4 | 0.12 | 0.5 | |||
| Cefepime | ≤0.06 to >64 | 4 | 32 | 82.1 | 7.5 | 10.5 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 2 | 8 | 91.6 | 0 | 8.4 | |
| Ceftolozane-tazobactam | ≤0.06 to >64 | 0.5 | 4 | 90.9 | 2.1 | 7.1 | |
| Ciprofloxacin | ≤0.12 to >8 | 0.25 | >8 | 74.0 | 4.1 | 22.0 | |
| Colistin | ≤0.25 to >8 | 1 | 2 | 98.7 | 0.5 | 0.8 | |
| Meropenem | ≤0.06 to >64 | 0.5 | 16 | 73.6 | 5.2 | 21.2 | |
| Meropenem-nonsusceptible Pseudomonas aeruginosa (202) | Cefiderocol | 0.008–4 | 0.25 | 1 | |||
| Cefepime | 1 to >64 | 16 | >64 | 47.5 | 18.3 | 34.2 | |
| Ceftazidime-avibactam | 1 to >64 | 8 | 64 | 68.3 | 0 | 31.7 | |
| Ceftolozane-tazobactam | 0.5 to >64 | 1 | >64 | 67.3 | 5.9 | 26.7 | |
| Ciprofloxacin | ≤0.12 to >8 | 8 | >8 | 34.7 | 5.0 | 60.4 | |
| Colistin | ≤0.25–4 | 1 | 1 | 99.0 | 1.0 | 0 | |
| Meropenem | 4 to >64 | 8 | 16 | 0 | 19.8 | 80.2 | |
| Acinetobacter baumannii (839) | Cefiderocol | 0.004–64 | 0.12 | 1 | |||
| Cefepime | ≤0.06 to >64 | 64 | >64 | 26.5 | 12.5 | 61.0 | |
| Ceftazidime-avibactam | ≤0.06 to >64 | 16 | >64 | ||||
| Ceftolozane-tazobactam | ≤0.06 to >64 | 8 | 64 | ||||
| Ciprofloxacin | ≤0.12 to >8 | >8 | >8 | 21.9 | 0.1 | 78.0 | |
| Colistin | ≤0.25 to >8 | 1 | >8 | 87.5 | 0 | 12.5 | |
| Meropenem | ≤0.06 to >64 | 32 | >64 | 29.1 | 0.6 | 70.3 | |
| Meropenem-nonsusceptible Acinetobacter baumannii (595) | Cefiderocol | 0.004–64 | 0.12 | 1 | |||
| Cefepime | 4 to >64 | 64 | >64 | 2.4 | 13.6 | 84.0 | |
| Ceftazidime-avibactam | 1 to >64 | 32 | >64 | ||||
| Ceftolozane-tazobactam | 1 to >64 | 16 | >64 | ||||
| Ciprofloxacin | ≤0.12 to >8 | >8 | >8 | 0.2 | 0 | 99.8 | |
| Colistin | ≤0.25 to >8 | 1 | >8 | 82.7 | 0 | 17.3 | |
| Meropenem | 4 to >64 | 64 | >64 | 0 | 0.8 | 99.2 | |
| Stenotrophomonas maltophilia (276) | Cefiderocol | 0.004–2 | 0.06 | 0.25 | |||
| Cefepime | 0.5 to >64 | 32 | >64 | ||||
| Ceftazidime-avibactam | 0.5 to >64 | 16 | 64 | ||||
| Ceftolozane-tazobactam | 0.12 to >64 | 8 | >64 | ||||
| Ciprofloxacin | ≤0.12 to >8 | 2 | 8 | ||||
| Colistin | ≤0.25 to >8 | 1 | >8 | ||||
| Meropenem | 0.12 to >64 | >64 | >64 | ||||
| Burkholderia cepacia (6) | Cefiderocol | 0.004–1 | |||||
| Cefepime | 16 to >64 | ||||||
| Ceftazidime-avibactam | 2–32 | ||||||
| Ceftolozane-tazobactam | 1–64 | ||||||
| Ciprofloxacin | 0.5 to >8 | ||||||
| Colistin | ≤0.25 to >8 | ||||||
| Meropenem | 2–16 | 66.7 | 0 | 33.3 | |||
a
MIC50 and MIC90 calculated only for genus or species where >30 isolates were tested. Species of Enterobacteriaceae with <30 isolates were grouped with the overall genus data.
b
Blank spaces mean that there are no CLSI, EUCAST, or FDA MIC breakpoints available for this agent.
c
The 1,021 isolates of Klebsiella spp. were composed of 761 Klebsiella pneumoniae and 260 Klebsiella oxytoca isolates.
d
The 493 isolates of Serratia spp. were composed of 455 Serratia marcescens, 33 Serratia liquefaciens, 3 Serratia ureilytica, 1 Serratia odorifera, and 1 Serratia rubidaea isolates.
e
The 530 isolates of Enterobacter spp. were composed of 301 Enterobacter cloacae, 204 Enterobacter aerogenes, 19 Enterobacter asburiae, 4 Enterobacter kobei, and 2 Enterobacter ludwigii isolates.
f
The 247 isolates of Citrobacter spp. were composed of 160 Citrobacter freundii, 73 Citrobacter koseri, 9 Citrobacter braakii, 3 Citrobacter amalonaticus, and 2 Citrobacter farmeri isolates.