TABLE 4.
In vitro antiviral effects of PC786 on selected RNA and DNA viruses
| Virus | Family | Cell type | PC786 |
||||
|---|---|---|---|---|---|---|---|
| IC50 (μM) | IC90 or IC95 (μM) | CC50 (μM) | Safety index | Selectivity index vs RSV | |||
| RSV A long | Paramyxoviridae | HEp-2 | <0.00042 | <0.00042 | >1.4 | >3,300 | |
| PIV3 | Paramyxoviridae | LLC-MK2a 7.1 | >14 | >14 | >14 | NA | >33,000 |
| Measles virus | Paramyxoviridae | MRC5 | >14 | >14 | >14 | NA | >33,000 |
| Influenza virus H1N1 | Orthmyxoviridae | A549 | >14 | >14 | >14 | NA | >33,000 |
| Hepatitis C virus | Flaviviridae | Huh-7, GT1b replicon | 0.32 | >14 | >14 | >44 | >762 |
| Rhinovirus 16 | Picornaviridae | HeLa | >14 | >14 | >14 | NA | >33,000 |
| HIV-1 | Retroviridae | CEM-SS | >14 | >14 | >14 | NA | >33,000 |
| Herpes simplex virus 1 | Herpesviridae | Vero | >14 | >14 | >14 | NA | >33,000 |
a
LLC-MK2 is a rhesus monkey kidney cell line.