TABLE 2.

Pharmacokinetic parameters for omadacycline (100 mg) and tigecycline (50 mg) in plasma infused i.v. over 30 min^a

Treatment	Cmax (μg/ml)	Cmin (μg/ml)	AUC0–taub (μg · h/ml)	Vss (liters)	CL (liters/h)	t1/2 (h)
Omadacyclinec	2.12 ± 0.68	0.28 ± 0.10	12.14 ± 3.22	190 ± 53	8.79 ± 2.21	16.0 ± 3.5
Tigecyclined	0.98 ± 0.21	0.11 ± 0.03	2.20 ± 0.42	315 ± 67	23.1 ± 4.1	11.4 ± 2.6

^aData are expressed as the mean ± SD. Abbreviations: C_max, maximum plasma concentration; C_min, minimum plasma concentration; AUC_0–tau, area under the plasma concentration-time curve for the dosing interval (tau); V_ss, apparent volume of distribution at steady state; CL, apparent clearance; t_1/2, elimination half-life.

^bTau (the end of the dosing interval) is 24 h for omadacycline (AUC_0–24) and 12 h for tigecycline (AUC_0–12).

^cParameter estimates for omadacycline in a total of 41 subjects following the fifth dose.

^dParameter estimates for tigecycline in a total of 17 subjects following the seventh dose.