TABLE 4.

Tigecycline concentrations in plasma (total), ELF, and AC at time of bronchoscopy and BAL^a

BAL fluid sampling time (h)b	Tigecycline concn (mg/liter)
	Plasma	ELF	AC
2	0.217 ± 0.051	0.553 ± 0.497	3.42 ± 2.17
4	0.159 ± 0.026	0.233 ± 0.070	4.68 ± 1.10
6	0.157 ± 0.036	0.268 ± 0.097	3.18 ± 0.88
12	0.121 ± 0.036c	0.149 ± 0.028d	2.44 ± 0.87

^aData are expressed as the mean ± SD at each sampling time. Abbreviations: BAL, bronchoalveolar lavage; ELF, epithelial lining fluid; AC, alveolar cells (macrophages).

^bSamples were obtained from 4 subjects per sampling time except at the 4-h sampling time, when samples were obtained from 5 subjects.

^cThree of 4 subjects had plasma samples available for assay at this sampling time.

^dTwo of 4 subjects had concentrations equal to or above the quantitative level of detection.