TABLE 1.
Antibacterial activities of thiram, disulfiram, and diethyldithiocarbamate compared to cefotaxime and vancomycina
| Speciesb | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
| THM | DSF | DDTC | CTX | VAN | |
| Enterococcus faecium (VRE) | 8 | 16 | 32 | >64 | |
| Staphylococcus aureus (MSSA) | 2 | 8 | 32 | 1 | |
| Staphylococcus aureus (MRSA) | 2 | 8 | 16 | 1 | |
| Staphylococcus epidermidis | 1 | 1 | 32 | 2 | |
| Acinetobacter baumannii | 32 | 64 | 64 | >64 | |
| Klebsiella pneumoniae | 32 | 64 | 32 | 8 | |
| Pseudomonas aeruginosa | >64 | >64 | >64 | 16 | |
| Enterobacter cloacae | 32 | 64 | >64 | 16 | |
| Escherichia coli | 64 | >64 | >64 | >64 | |
a
THM, thiram; DSF, disulfiram; DDTC, diethyldithiocarbamate; CTX, cefotaxime; VAN, vancomycin.
b
The species examined included E. faecium ATCC 700221 (VanA type VRE), S. aureus ATCC 25293 (MSSA), S. aureus COL (MRSA), S. epidermidis ATCC 14990, A. baumannii ATCC 19606, E. cloacae ATCC 13047, E. coli BAA-2326 (EHEC O104:H4; ESBL producer), K. pneumoniae ATCC 700603 (K6; ESBL producer), and P. aeruginosa ATCC 15442.