. 2017 Aug 24;61(9):e00898-17. doi: 10.1128/AAC.00898-17

TABLE 3.

Comparison of disulfiram MIC₅₀ and MIC₉₀ values to other test agents against S. aureus

Variant (no. of strains)^a	Test agent^b	MIC (μg/ml)
Variant (no. of strains)^a	Test agent^b	MIC₅₀	MIC₉₀	Range
VSSA (10)^c	THM	2	4	2 to 4
	DSF	8	16	8 to 32
	DDTC	32	64	16 to >64
	OXA	64	>64	≤0.5 to >64
	VAN	1	1	1 to 2
VISA (10)^d	THM	2	4	2 to 8
	DSF	16	16	4 to 32
	DDTC	32	64	16 to 64
	OXA	>64	>64	≤0.5 to >64
	VAN	4	8	4 to 8
VRSA (10)^e	THM	1	2	1 to 2
	DSF	16	16	4 to 32
	DDTC	32	32	8 to 64
	OXA	256	>256	128 to >256
	VAN	256	>256	64 to >256

VSSA, vancomycin-susceptible S. aureus (VAN MIC ≤ 2 μg/ml); VISA, vancomycin-intermediate S. aureus (VAN MIC = 4 to 8 μg/ml); VRSA, vancomycin-resistant S. aureus (VAN MIC ≥ 16 μg/ml).

THM, thiram; DSF, disulfiram; DDTC, diethyldithiocarbamate; OXA, oxacillin; VAN, vancomycin.

VSSA strains: MSSA (ATCC 25923, NCTC 8325); MRSA (C1999000193, CA-347, CM05, COL, JE2, N315, SA LinR #14, USA300-0114).

VISA strains: AR-215 to AR-224.

VRSA strains: 71080, AIS 080003, AIS 1000505, AIS 2006032, AIS 2006045, HIP11714, HIP11983, HIP13419, HIP14300, and HIP15178.