FIG 2.

Changes in HBV markers in mice treated with high-dose antivirals. (A to B) HBV-infected mice were treated with either 20 mg/kg or 100 mg/kg of entecavir (ETV) daily for 4 weeks (A) or 300 μg/kg of PEG-IFN-α-2a twice weekly for 6 weeks (B). (C and D) Three mice were treated with 20 mg/kg of entecavir daily and 300 μg/kg of PEG-IFN twice weekly for 6 weeks. (C) The time course of serum HBV DNA titer in each mouse. (D) Serum HBsAg, HBeAg, and HBcrAg levels in each mouse at baseline and after 6 weeks of treatment in three mice.