FIG 3.
Target attainment probability and cumulative fraction of response for various ertapenem doses. (A) Target attainment probability for %TMIC of 40% as M. tuberculosis MIC changes. No dose or dosing schedule is effective once MICs are 16 mg/liter. (B) Ertapenem MIC distribution in isolates from The Netherlands, with and without transformation to account for ertapenem degradation. (C) Proportion of 10,000 patients who achieved or exceeded a %TMIC of 40% with once-a-day dosing. The proportion is highly sensitive to the MIC and fell on sensitivity analysis, a worst-case scenario. (D) Proportion of 10,000 patients who achieved or exceeded a %TMIC of 40% with twice-a-day dosing. The twice-a-day dosing schedule achieved the target in higher proportions of patients, even on sensitivity analysis. However, given the hardship of twice a day administration of therapy in TB, we chose the dosage of 2 g once a day as being most practical.