TABLE 2.

Comparison of pharmacokinetic parameter and concentration estimates and ranges in 10,000 simulated patients to those actually observed in patients treated with 1 g

Parameter	Value
	Subroutine prior based on literature, mean ± SD	For 10,000 simulated TB patients, mean (range)	Observed in MDR-TB patients, mean (range) (13)
Total clearance, liters/h	2.63 ± 0.83	2.6 (0.02–6.00)	2.1 (0.09–3.23)
Vol, liters	10.6 ± 2.51	11 (1.2–19)	7.3 (2.61–11.10)
Half-life, h		2.8 (2.20–3.70)	2.4 (2.05–3.53)
AUC0–24, mg · h/liter		448 (166–4,255)	545 (309–1,130)