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Diflunisal inhibits intracellular growth of F. tularensis LVS in macrophages and 293T/17 cells. Macrophages (a) and 293T/17 (b) cells were infected with F. tularensis LVS bacteria for 2 h, treated with gentamicin to kill extracellular bacteria, and then cocultured with 4× MIC of diflunisal for 22 h. ***, P < 0.001, comparing results with diflunisal to those with the DMSO control at the 24-h time point using two-way ANOVA with a Bonferroni posttest correction.
