TABLE 2.
Pharmacokinetic profile of single-dose AmBisome in plasma of L. donovani-infected BALB/c micea
| Parameter | Result for parameter at single i.v. dose shown |
||
|---|---|---|---|
| 10 mg/kg | 2.5 mg/kg | 0.6 mg/kg | |
| t1/2 (h) | 3.4 | 5.0 | NQ |
| Tmax (h) | 0.08 | 0.08 | 0.08 |
| Cmax (μg/ml) | 240.3 | 29.8 | 3.3 |
| AUClast (h · μg/ml) | 368.5 | 50.5 | 10.8 |
| CL (ml/h/kg) | 27.0 | 48.1 | 41.9 |
| V (ml/kg) | 104 | 252 | 681 |
a
Mice had been infected for 14 days at the time of dosing. The parasite burdens in untreated controls (mean ± SD) were 644 ± 25 LDU in the liver and 17 ± 1 LDU in the spleen (n = 3). Data are representative of two separate experiments (n = 1 mouse/time point). NQ, not quoted.