TABLE 2.
Extrapolated %f TMICa achieved with a human exposure of 2 g cefiderocol every 8 h as a 1- or 3-h infusion in infected rats
| Cefiderocol MIC (μg/ml) | %f TMIC with an infusion time of: |
|
|---|---|---|
| 1 h | 3 h | |
| 0.125 | 100 | 100 |
| 0.25 | 100 | 100 |
| 0.5 | 100 | 100 |
| 1 | 100 | 100 |
| 2 | 100 | 100 |
| 4 | 75 | 100 |
| 8 | 50 | 100 |
%fTMIC, percentage of the dosing interval during which free drug concentrations are above the MIC.