FIG 3.

Lethal factor levels during ciprofloxacin treatment with and without β-lactam and/or protein synthesis (PS) inhibitors for ciprofloxacin-resistant Bacillus anthracis. Means and standard deviations (error bars) are from lethal factor levels measured in plasma from three mice per time point per group. (A) SWI and ciprofloxacin (cipro) only controls. (B) Ciprofloxacin (cip) and meropenem (mer) with PS inhibitors linezolid (lin), clindamycin (cli), rifampin (rif), or doxycycline (dox). (C) Ciprofloxacin and penicillin (pen) with linezolid or doxycycline. (D) Ciprofloxacin and rifampin with linezolid or clindamycin. Individual mouse samples below the limit of detection (LOD) of 0.005 ng/ml (dashed lines) were given a value of one-half the LOD (0.0025 ng/ml), per Hornung et al. (21), for inclusion and appropriate weighting of the means.