TABLE 4.
Tested antimicrobial agents and dilution ranges
Antimicrobial | Companya | Order no. | Dilution range (mg/liter) |
Breakpoint (mg/liter)b | Stock concn (mg/ml), diluentc | |
---|---|---|---|---|---|---|
B. burgdorferi sensu lato | Relapsing-fever Borrelia strains | |||||
Amoxicillin | Centrafarm | 14029596 | 0.25–128 | 0.25–128 | ≤4 | 8.89, PBS |
Doxycycline | Sigma-Aldrich | D3447 | 0.03–8 | 0.004–2 | ≤4 | 44.4, DMSO |
Ceftriaxone | Sigma-Aldrich | PHR1382 | 0.008–4 | 0.008–4 | ≤8 | 4.44, PBS |
Azithromycin | Sigma-Aldrich | PHR1088 | 0.0001–0.05 | 0.0001–0.05 | ≤2 | 5.56, DMSO |
Amikacin | Sigma-Aldrich | A1774 | 2–1,024 | 2–1,024 | ≤16 | 11.26, MKP |
Locations: Centrafarm, Etten-Leur, the Netherlands; Sigma-Aldrich, St. Louis, MO, USA.
According to the Clinical and Laboratory Standards Institute.
PBS, phosphate-buffered saline; DMSO, dimethyl sulfoxide; MKP, modified Kelly-Pettenkofer medium. The DMSO concentrations used in our studies did not influence Borrelia viability (data not shown).