TABLE 1.

Intracellular uptake of EMB in resting and activated primary macrophages of mouse and human origin and in THP-1 cells

Infection status	Intracellular uptake in BMDMb
	Human			Mousec			THP-1
	Donor 1	Donor 2	Donor 3	M0	M1	M2
Uninfected	21.96 ± 2.78	14.98 ± 2.03	10.28 ± 8.46	6.79 ± 1.72	5.18 ± 0.90	12.44 ± 3.94	5.00 ± 1.70
Infecteda	19.64 ± 3.84	11.06 ± 1.55	14.02 ± 9.82	NDd	ND	ND	ND

^aInfected with gamma-irradiated (inactivated) M. tuberculosis.

^bIntracellular uptake was determined as the intracellular-to-extracellular concentration ratio. BMDM, bone marrow-derived macrophages.

^cM0, resting macrophages; M1, macrophages subjected to classical activation; M2, macrophages subjected to alternate activation (see Materials and Methods).

^dND, not detected.