TABLE 3.
Nafithromycin concentrations in plasma, ELF, and AM at time of bronchoscopy and BALa
| Sampling time (h) | Nafithromycin concn (mg/liter) in: |
||
|---|---|---|---|
| Plasma | ELF | AM | |
| 3b | 1.105 ± 0.140 | 18.48 ± 12.31 | 290.2 ± 179.0 |
| 6b | 0.966 ± 0.439 | 15.29 ± 14.53 | 375.4 ± 218.2 |
| 9b | 0.922 ± 0.286 | 8.37 ± 4.38 | 401.1 ± 420.3 |
| 12c | 0.817 ± 0.261 | 9.67 ± 6.20 | 729.4 ± 739.0 |
| 24d | 0.239 ± 0.055 | 4.13 ± 1.38 | 120.9 ± 66.2 |
| 48b | 0.060 ± 0.029 | 1.62 ± 0.86 | 22.4 ± 10.4 |
a
Data are expressed as the mean ± 1 SD.
b
Data are for six concentrations per matrix at this sampling time.
c
Data are for five concentrations per matrix at this sampling time.
d
Data are for six plasma and ELF concentrations and five AM concentrations at this sampling time.