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Colistin concentrations during morbidostat culture of PA77. The colistin concentration necessary to inhibit growth in the morbidostat increased much more dramatically than MICs measured in Etests. Colistin concentrations are given in units of the MIC of the initial cultures (2.8 μg/ml). The MICs determined by broth microdilution are indicated by the black diamond (initial strain) and isolated colored symbols (endpoints of each vial).
