TABLE 3.
PTA at 72 h after VA ECMO initiation and at 72 h after VA ECMO discontinuation, using eight different dosing regimens, stratified by use of CRRTa
| Dosing regimenb | Use of CRRT | PTA (%) at 72 h after ECMO initiation |
PTA (%) at 72 h after ECMO discontinuation |
||
|---|---|---|---|---|---|
| Mild to moderate infections | Severe infections | Mild to moderate infections | Severe infections | ||
| A (LD, 400; MD, 400) | Yes | 5.62 | 0.30 | 58.6 | 26.8 |
| No | 22.8 | 3.16 | 63.1 | 36.0 | |
| B (LD, 600; MD, 400) | Yes | 24.6 | 3.14 | 62.9 | 32.9 |
| No | 50.1 | 15.2 | 65.4 | 39.7 | |
| C (LD, 600; MD, 600) | Yes | 34.8 | 5.74 | 82.0 | 58.5 |
| No | 59.5 | 22.9 | 82.6 | 63.0 | |
| D (LD, 800; MD, 600) | Yes | 56.1 | 17.6 | 83.2 | 61.7 |
| No | 75.5 | 41.6 | 83.2 | 64.6 | |
| E (LD, 800; MD, 800) | Yes | 64.3 | 23.3 | 91.6 | 76.3 |
| No | 81.0 | 49.1 | 91.2 | 77.5 | |
| F (LD, 1,000; MD, 800) | Yes | 78.2 | 39.9 | 92.0 | 77.3 |
| No | 87.7 | 62.7 | 91.3 | 78.1 | |
| G (LD, 1,000; MD, 1,000) | Yes | 82.5 | 45.8 | 95.7 | 86.2 |
| No | 90.3 | 68.3 | 95.0 | 86.3 | |
| H (LD, 1,200; MD, 1,000) | Yes | 88.6 | 58.9 | 95.8 | 86.9 |
| No | 93.4 | 77.4 | 95.1 | 86.5 | |
a
The Ctrough target was set at >10 μg/ml for mild to moderate infections and >15 μg/ml for severe infections. PTA, probability of target attainment; ECMO, extracorporeal membrane oxygenation; LD, loading dose; MD, maintenance dose; CRRT, continuous renal replacement therapy.
b
The loading doses (in milligrams) were administered q12h, and the maintenance doses (in milligrams) were administered q24h.