FIG 1.

Prophylaxis with VT-1161 protects immunosuppressed mice from R. arrhizus var. arrhizus pulmonary infection. (A) Survival of mice (n = 20 per group from two independent experiments with similar results) treated prophylactically (day −2 until day 0) with VT-1161 or POS (POS-P) and then infected with R. arrhizus (average inhaled inoculum, 7.6 × 10³ per mouse). Mice treated with POS after infection (i.e., delayed therapy, starting on day +1 and ending on day +7 [POS-D]) were included as a historical positive control of efficacy (15). (B) Lungs and brains of mice (n = 17 to 19 per group from two independent experiments with similar results) were harvested on day +4. Data are expressed as medians ± interquartile range. *, P < 0.03 versus placebo mice; **, P < 0.008 versus placebo and POS prophylaxis by the log rank test; ‡, P < 0.05 versus placebo by the Wilcoxon rank sum test.