FIG 4.
Effect of 10 μM rilpivirine and 2 μM GF120918 on bidirectional permeation of 300 nM abacavir through Caco-2 monolayers. Apical-to-basolateral (A-to-B) Papp (black columns) or basolateral-to-apical (B-to-A) Papp (white columns) after 1 h of incubation with or without rilpivirine or GF120918 is shown. The efflux ratio (ER) was defined as the B-to-A Papp divided by the A-to-B Papp. Data are shown as mean values ± SD from three experiments performed in duplicate. Statistical significance was analyzed by Student's t test. ***, P ≤ 0.001; ns, not significant.