FIG 3.

Ultrastructure of T. gondii tachyzoites grown in HFFs and treated with ruthenium complexes 1 and 9. Treatments were carried out using 200 nM complex 1 (A to D) or complex 9 (E, F). (A) Low-magnification view of parasites treated with complex 1 for 6 h. The boxed areas are enlarged in panels B and C. (D) Parasites exposed to complex 1 for 48 h. (E, F) Parasites exposed to complex 9 for 24 h. Note the distinct alterations in the mitochondria (mito) in panels B, C, and E and the still intact host cell mitochondria (h-mito) in panel D. The boxed area in panel F is enlarged in panel E. Bars = 1 μm (A, F), 0.4 μm (B, C, E), and 0.8 μm (D).